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Updated: Sep 23, 2026
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Published on: January 21, 2012
[Study of RB gene in carcinoma of larynx]
Binquan Wang1, Yanqiu Chen, Shuxin Wen
1Department of Otorhinolaryngology, First Clinical Hospital, Shanxi Medical University, Taiyuan 030001.
Objective:
To probe the mutations of RB gene in laryngeal carcinoma, and the relation between it and the clinical phase.
Method:
The mutations were detected by PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism).
Result:
In laryngeal carcinoma, the mutations were identified in 14(15.5%) of 90 samples, of which 2 were large deletion, 12 were abnormal in electrophoresis of SSCP. The mutations of I-II stage tumor were 5(13.9%), of III-IV were 9(16.7%), there wasn't a significant difference between them.
Conclusion:
RB gene mutation takes part in the development of laryngeal carcinoma. But there wasn't relation between RB gene mutation and the course of laryngeal carcinoma.
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