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Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Implication of cardiac remodeling in heart failure: mechanisms and therapeutic strategies

Hiroyuki Takano1, Hiroshi Hasegawa, Toshio Nagai

  • 1Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba.

Internal Medicine (Tokyo, Japan)
|July 15, 2003
PubMed

Insights

Cardiac remodeling, a process involving heart muscle and other cells, contributes to cardiovascular disease progression. Modulating this process offers a promising strategy for preventing heart failure.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Pathophysiology

Background:

  • Left ventricular remodeling is a key factor in the progression of cardiovascular diseases.
  • This process involves cardiac myocytes, fibroblasts, extracellular matrix, and vasculature.
  • Remodeling is influenced by neurohumoral factors, cytokines, enzymes, and stress.

Purpose of the Study:

  • To review the evolving concept and clinical implications of cardiac remodeling.
  • To elucidate the molecular mechanisms underlying cardiac remodeling.
  • To explore novel therapeutic strategies targeting cardiac remodeling for heart failure.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Analysis of molecular mediators and cellular components involved in remodeling.
  • Evaluation of therapeutic interventions aimed at modulating cardiac remodeling.

Main Results:

  • Cardiac remodeling, initially adaptive, becomes maladaptive, leading to decompensation.
  • Numerous molecular and cellular factors contribute to the remodeling process.
  • Targeting remodeling pathways shows potential in preventing heart failure progression.

Conclusions:

  • Understanding cardiac remodeling is crucial for managing cardiovascular diseases.
  • Modulation of cardiac remodeling is an effective strategy to prevent heart failure.
  • Further research into molecular mechanisms can yield novel therapeutic targets.

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