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Influence of ocular tropicamide on exercise testing.

A Pines¹, E Z Fisman, Y Drory

¹Department of Medicine T, Ichilov Hospital, Tel-Aviv, Israel.

|January 1, 1992

Summary

Tropicamide eye drops can affect cardiovascular readings during exercise tests, particularly at lower work levels. However, the drug does not impact a patient's maximum exercise capacity or overall stress test results.

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Area of Science:

Cardiology
Ophthalmology
Exercise Physiology

Background:

Tropicamide is an anticholinergic medication commonly used for ophthalmic examinations.
Its potential systemic effects, particularly on cardiovascular parameters during physiological stress, are not fully understood.

Purpose of the Study:

To evaluate the impact of tropicamide 0.5% eye drops on cardiovascular parameters during exercise testing in healthy individuals.
To determine if pupil dilation influences these cardiovascular responses.

Main Methods:

154 healthy subjects underwent exercise testing, divided into three groups based on pupil dilation (not dilated, partially dilated, widely dilated).
A control group of 66 healthy individuals not receiving tropicamide was included for comparison.
Resting and exercise cardiovascular parameters (heart rate, blood pressure) were measured and compared across groups.

Main Results:

Tropicamide affected resting and exercise cardiovascular parameters in subjects with non-dilated and partially dilated pupils.
Subjects with widely dilated pupils showed results similar to controls.
The study group, as a whole, achieved higher workloads than controls (126 vs. 119 W).

Conclusions:

Ocular tropicamide instillation demonstrably affects cardiovascular parameters at rest and during exercise.
A lower heart rate was observed at initial exercise levels in subjects using tropicamide.
Tropicamide does not alter the ability to reach target heart rate or affect overall stress test outcomes at symptom-limited levels.