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Hyperpolarized 13C MR angiography using trueFISP.

Jonas Svensson1, Sven Månsson, Edvin Johansson

  • 1Department of Radiation Physics, Malmö University Hospital, Lund University, Malmö, Sweden. jonas.svensson@rfa.mas.lu.se

Magnetic Resonance in Medicine
|July 24, 2003
PubMed
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A novel hyperpolarized (13)C contrast agent was developed for enhanced magnetic resonance angiography (CE-MRA). This agent enables clear visualization of blood vessels in live rats, demonstrating its potential for advanced medical imaging.

Area of Science:

  • Medical Imaging
  • Biophysics
  • Radiology

Background:

  • Dynamic nuclear polarization (DNP) enhances nuclear spin polarization.
  • Contrast-enhanced magnetic resonance angiography (CE-MRA) visualizes blood vessels.
  • Developing novel contrast agents is crucial for improving CE-MRA.

Purpose of the Study:

  • To develop and evaluate a (13)C-enriched water-soluble compound as a contrast medium for CE-MRA.
  • To assess the efficacy of this agent in visualizing vasculature in vivo.

Main Methods:

  • A (13)C-enriched cyclopropane derivative was synthesized and hyperpolarized using DNP.
  • The compound was administered intravenously to anesthetized rats for CE-MRA.
  • Steady-state free precession (SSFP) imaging with a trueFISP pulse sequence was employed.

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  • A flip-back technique was used to preserve magnetization between acquisitions.

    • Main Results:

    • The hyperpolarized (13)C contrast agent achieved approximately 15% polarization.
    • Long relaxation times (T(1), T(2)) were observed, suitable for SSFP imaging.
    • High signal-to-noise ratios (SNR) were achieved for major vessels (e.g., vena cava SNR ~240, aorta, carotid arteries SNR ~75, cardiac region SNR ~500).
    • Vessel visualization was maintained across 15 consecutive images using the flip-back technique.

    Conclusions:

    • The developed (13)C contrast agent is effective for CE-MRA in live rats.
    • The agent's properties and the imaging technique allow for detailed visualization of the vasculature.
    • This approach holds promise for future advancements in non-invasive vascular imaging.