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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Quality of platelet concentrates derived by platelet rich plasma, buffy coat and Apheresis

Eugenia Vasconcelos1, A C Figueiredo, Jerard Seghatchian

  • 1Centro Regional de Sangue de Lisboa, Instituto Português do Sangue, Lisboa, Portugal. evasconcelos@netcabo.pt

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|July 25, 2003
PubMed

Platelets derived from platelet rich plasma, buffy coat and Apheresis technologies differ in terms of in vitro functional activity, aggregation states and storage characteristics, as measured by automated cell counters, and pH assessment. This may be related to either differences in the subpopulation of platelets and leucocytes recovered or the processing/storage induced cellular damage. Some types of methodologies, such as BC derived-PC, appear to have a higher rate of bacterial contamination.

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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