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Annular erythema responding to tacrolimus ointment.
Nikhil G Rao1, Robert J Pariser
1University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Journal of Drugs in Dermatology : JDD
|July 30, 2003
Summary
Topical tacrolimus ointment effectively treated two cases of difficult annular erythema resistant to corticosteroids. This finding suggests tacrolimus as a potential therapy for this unusual skin condition.
Area of Science:
- Dermatology
- Immunology
Background:
- Annular erythema is an uncommon skin condition, often idiopathic.
- It typically shows poor response to standard topical treatments, including corticosteroids.
Observation:
- Two patients with corticosteroid-resistant annular erythema were treated with 0.1% tacrolimus ointment.
- Lesions cleared promptly in treated areas, while untreated areas persisted.
Findings:
- Topical tacrolimus ointment 0.1% demonstrated a clear therapeutic effect on chronic, corticosteroid-resistant annular erythema.
- The observed response suggests tacrolimus's efficacy in managing this specific dermatological disorder.
Implications:
- Tacrolimus ointment may offer a valuable treatment option for recalcitrant annular erythema.
- Further controlled studies are warranted to confirm the potential of tacrolimus in treating annular erythema.