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[Study on the relationship between angiogenesis and cervical lymphatic metastasis in head and neck squamous cell
1Department of Otolaryngology, First Hospital, Medical College, Zhejiang University, Hangzhou 310003.
Objective:
To investigate the relationship between tumor angiogenesis and cervical lymphatic metastasis and the expression of vascular endothelial growth factor in head and neck squamous cell carcinomas.
Method:
Fifty-eight head and neck carcinoma tissue slides were immunohistochemically stained for anti-CD34 monoclonal antibody and anti-VEGF polyclonal antibody by SABC method. The intratumor microvessel density (IMVD) and the expression of vascular endothelial growth factor were measured.
Result:
1. The mean IMVD with cervical lymphatic metastasis was significantly higher than those without cervical lymphatic metastasis in head and neck squamous cell carcinomas(27.92 +/- 9.11 and 20.69 +/- 7.08, P < 0.01); 2. The expression of vascular endothelial growth factor had a positive correlation with IMVD in head and neck carcinoma tissues (rs = 0.487, P < 0.01).
Conclusion:
IMVD may be an important predictor to cervical lymphatic metastasis in head and neck squamous cell carcinomas. Vascular endothelial growth factor may stimulate tumor angiogenesis in head and neck squamous cell carcinomas.
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