Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complex aphthosis.

Roy S Rogers1

  • 1Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Advances in Experimental Medicine and Biology
|August 16, 2003
PubMed
Summary
This summary is machine-generated.

Complex aphthosis, characterized by recurrent aphthous stomatitis, is not Behçet's disease (BD) alone. Evaluation for correctable causes of aphthosis is crucial, as complex aphthosis can mimic BD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reactive nonsexually related acute genital ulcers: A retrospective analysis of the Mayo Clinic experience.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

The dermatologic oral examination and biopsy: A guide for incorporation into everyday practice.

Journal of the American Academy of Dermatology·2025
Same author

The dermatologic oral examination: Navigating the Oral Dermatoses Map.

Journal of the American Academy of Dermatology·2025
Same author

Empiric intralesional tumescent drug delivery of antimicrobials effectively treated a painful necrotizing skin infection.

JAAD case reports·2024
Same author

Dermatologic manifestations of zoonotic diseases transmitted by dogs: "Spot" could give you spots.

International journal of dermatology·2024
Same author

Coexistence of oral lichen planus and vulvar lichen sclerosus.

Oral surgery, oral medicine, oral pathology and oral radiology·2023
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Area of Science:

  • Oral Medicine
  • Immunodermatology
  • Rheumatology

Background:

  • Behçet's disease (BD) diagnosis requires specific criteria, often including characteristic oral aphthous ulcers.
  • Complex aphthosis, a severe form of recurrent aphthous stomatitis, can clinically resemble the oral manifestations of BD.
  • Distinguishing between complex aphthosis and BD is critical for appropriate patient management.

Purpose of the Study:

  • To clarify the relationship between complex aphthosis and Behçet's disease.
  • To emphasize the importance of evaluating complex aphthosis for underlying or associated conditions.
  • To highlight complex aphthosis as a significant differential diagnosis in suspected BD cases.

Main Methods:

  • Clinical observation and case review of patients presenting with complex aphthosis.

Related Experiment Videos

  • Differential diagnostic analysis comparing features of complex aphthosis and Behçet's disease.
  • Literature review on aphthosis and Behçet's disease.

    • Main Results:

    • Complex aphthosis alone does not meet the diagnostic criteria for Behçet's disease.
    • Patients with complex aphthosis require thorough evaluation for associated conditions, including potentially "correctable causes" of aphthous stomatitis.
    • Complex aphthosis is frequently encountered as a pseudo-Behçet's disease in specialized practices.

    Conclusions:

    • Oral aphthous lesions in Behçet's disease are best classified as complex aphthosis.
    • Some individuals with complex aphthosis may eventually develop BD, while others may have persistent aphthosis without BD.
    • Identifying treatable underlying causes is essential for managing patients with complex aphthosis.