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The prognostic value of circulating soluble cell adhesion molecules in patients with chronic congestive heart failure

Wei-Hsian Yin1, Jaw-Wen Chen, Hsu-Lung Jen

  • 1Division of Cardiology, Cheng-Hsin General Hospital, 45, Cheng-Hsin Street, Pei-Tou, Taipei, Taiwan, ROC.

European Journal of Heart Failure
|August 19, 2003
PubMed

Insights

Soluble cell adhesion molecules (sCAMs) are elevated in heart failure patients. High sP-selectin levels independently predict adverse outcomes in congestive heart failure (CHF), offering prognostic value.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biomarkers

Background:

  • Soluble cell adhesion molecules (sCAMs) are elevated in congestive heart failure (CHF).
  • sCAMs may influence CHF pathogenesis via immune response modulation.
  • Prognostic data on sCAMs in CHF patients are limited.

Purpose of the Study:

  • To assess the prognostic value of circulating sCAMs in patients with CHF.
  • To investigate the relationship between sCAM levels and clinical outcomes in CHF.

Main Methods:

  • Measured circulating levels of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and sP-selectin in 74 CHF patients.
  • Compared sCAM levels with 19 age-matched controls.
  • Tracked major adverse cardiac events over a median 240-day follow-up.

Main Results:

  • sCAM levels were higher in CHF patients than controls and correlated with CHF severity.
  • Elevated sCAM levels were associated with major adverse cardiac events.
  • High sP-selectin was an independent predictor of CHF events via Cox analysis.

Conclusions:

  • sCAM levels increase with CHF severity and correlate with clinical outcomes.
  • High sP-selectin levels provide independent prognostic information in CHF patients.
Abstract

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