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Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis
Matthew J Gaunt1, Helen F Sneddon, Peter R Hewitt
1University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.
Organic & Biomolecular Chemistry
|August 22, 2003
Abstract:
beta-Keto 1,3-dithianes can be generated by the double conjugate addition of dithiols to propargylic ketones, esters and aldehydes in excellent yields. As masked 1,3-dicarbonyl systems these substrates can be converted to a range of functionalised oxygen-containing heterocycles that can be used in natural product synthesis.