Related Experiment Video
Updated: Sep 20, 2026
Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
[Expression of monocyte chemoattractant protein-1 in aorta of early hypertensive rats]
Qi-ying Xie1, Ming Sun, Tian-lun Yang
1Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China.
Objective:
To investigate the expression of monocyte chemoattractant protein-1(MCP-1) of aorta wall in acute phase of hypertension in rats with 2 kidney and 1 clip(2K1C).
Method:
The MCP-1 mRNA on aorta wall was detected by in situ hybridization and reverse transcription-polymerase chain reaction(RT-PCR).
Results:
No MCP-1 was expressed in normal rat, but it was expressed on the aorta wall of rats in 1 week after 2K1C hypertensive model was formed. The expression of MCP-1 increased with the development of hypertension.
Conclusion:
The expression of MCP-1 on aorta wall of 2K1C hypertensive rats increases in the early stage of hypertension, which may play an important role in accelerating atherosclerosis.
