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Updated: Aug 13, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
[Biological availability of ibuprofen in Imbun 500 suppositories]
1Katedra i Zakład Chemii Fizycznej Akademii Medycznej im. K. Marcinkowskiego w Poznaniu, ul. Swiecickiego 6, 60-781 Poznań.
Abstract:
Concentration of ibuprofen in rabbit blood was found to be considerably higher after application of Imbun-500 suppositories, containing 500 mg of ibuprofen lysine salt equivalent to 292.6 mg of free ibuprofen, than after application of ibuprofen dragees containing 400 mg of the free drug. Parameters characterizing biological availability of ibuprofen in Imbun-500 suppositories (AUC, Cmax, tmax) were determined. Ibuprofen lysine salt proved to be considerably more easily absorbed from suppositories than ibuprofen from dragees of either home or foreign production.
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