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[Small cell carcinoma of urinary bladder. A case report]
M Suzuki1, A Kuroda, K Nakauchi
1Department of Urology, Hoshi General Hospital.
Summary
A rare small cell undifferentiated carcinoma of the urinary bladder presented with severe lumbar pain and hematuria. This aggressive cancer, diagnosed via biopsy and imaging, led to the patient's death within five months.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Small cell carcinoma is a rare and aggressive malignancy that can occur in the urinary bladder.
- Early diagnosis and understanding its presentation are crucial for patient outcomes.
Observation:
- A 57-year-old male presented with severe lumbar pain and gross hematuria.
- Physical examination revealed a pelvic mass; cystoscopy showed a large intravesical tumor.
- Elevated tumor markers (CEA, TPA, CA19-9, NSE) and CT/bone scan findings indicated an advanced, metastatic tumor.
Findings:
- Transurethral biopsy confirmed small cell undifferentiated carcinoma of the urinary bladder.
- Histopathology showed small tumor cells in sheet and solid patterns, positive for NSE and NF stains.
- The tumor originated from the anterior vesical wall with bone metastases.
Implications:
- This case highlights the aggressive nature of small cell urinary bladder cancer.
- Prompt diagnosis through cystoscopy, tumor markers, and biopsy is essential.
- Despite aggressive treatment, the prognosis remains poor, emphasizing the need for further research into effective therapies.