Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple metabotropic glutamate receptors regulate hippocampal function.

M A Desai1, T S Smith, P J Conn

  • 1Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322.

Synapse (New York, N.Y.)
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gun-Shot Wound of the Brain.

Iowa medical journal·2023
Same author

Coupled Sublattice Melting and Charge-Order Transition in Two Dimensions.

Physical review letters·2020
Same author

Description, characterization, and evaluation of an online social networking community: the American Cancer Society's Cancer Survivors Network®.

Journal of cancer survivorship : research and practice·2018
Same author

Prevalence of exon 11 internal tandem duplications in the C-KIT proto-oncogene in Australian canine mast cell tumours.

Australian veterinary journal·2017
Same author

Proteomic approach to characterize biochemistry of meat quality defects.

Meat science·2017
Same author

Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice.

ACS chemical neuroscience·2015
Same journal

LncRNA MIAT Protects Against Sevoflurane-Induced Cognitive Dysfunction in Neonatal Rats via the miR-15b-5p/Ccnd1 Axis.

Synapse (New York, N.Y.)·2026
Same journal

A Survey of Automatic Sleep Staging: Technical Route, Technical Challenges, and Future Perspectives.

Synapse (New York, N.Y.)·2026
Same journal

Structural Architecture and Evolutionary Conservation of Cerebellin-Mediated Trans-Synaptic Signaling.

Synapse (New York, N.Y.)·2026
Same journal

Correction to "Time of Day Does Not Impact Spinal Serotonin Levels in Humans".

Synapse (New York, N.Y.)·2026
Same journal

Effect of Healthy Aging on the Cytoarchitecture of Layer V Pyramidal Neurons in the Motor Cortex of Rats: A Golgi Study.

Synapse (New York, N.Y.)·2026
Same journal

Ketamine Responsiveness of Mice Exhibiting Anorexia-Like Behavior Correlates With Synaptic AMPA Receptor Distribution.

Synapse (New York, N.Y.)·2026
See all related articles

Selective activation of metabotropic glutamate receptors (mGluRs) by trans-ACPD in the hippocampus involves distinct receptor subtypes. These findings differentiate mGluRs not linked to phosphoinositide hydrolysis from those that are.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Metabotropic glutamate receptors (mGluRs) modulate neuronal activity.
  • Selective activation of mGluRs with trans-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) affects hippocampal CA1 pyramidal cells.
  • trans-ACPD elicits excitation, blocks inhibition, and reduces synaptic transmission via phosphoinositide hydrolysis.

Purpose of the Study:

  • To determine if the physiological effects of trans-ACPD in the hippocampus are mediated by phosphoinositide hydrolysis-linked mGluRs.
  • To investigate the roles of different mGluR subtypes in hippocampal function.

Main Methods:

  • Utilized L-2-amino-3-phosphonopropionic acid (L-AP3) as an antagonist for phosphoinositide hydrolysis.
  • Administered specific trans-ACPD stereoisomers (1S,3S-ACPD, 1R,3S-ACPD, 1S,3R-ACPD) to hippocampal slices.

Related Experiment Videos

  • Measured evoked field excitatory postsynaptic potentials (EPSPs) and phosphoinositide hydrolysis.

    • Main Results:

    • L-AP3 did not inhibit trans-ACPD's physiological effects at effective concentrations.
    • 1S,3S-ACPD activated phosphoinositide hydrolysis but did not alter evoked EPSPs.
    • 1R,3S- and 1S,3R-ACPD isomers induced physiological effects consistent with mGluR activation.

    Conclusions:

    • The physiological effects of trans-ACPD in hippocampal area CA1 are mediated by mGluRs.
    • These effects are likely due to activation of mGluR subtypes distinct from the AP3-sensitive, phosphoinositide hydrolysis-linked receptor.