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Acute respiratory failure during pneumonia induced by Sendai virus
G J van Daal1, E P Eijking, K L So
1Dept of Anesthesiology, Erasmus University Rotterdam, The Netherlands.
Advances in Experimental Medicine and Biology
|January 1, 1992
Abstract:
In this study a model of acute respiratory failure due to viral pneumonia in rats, closely resembling ARDS, is presented. Severe respiratory failure with lethal outcome in four days was induced by infection concentrated Sendai virus aerosol. This model permits evaluation of different therapeutical approaches for improving gas exchange during ARDS. Furthermore, preliminary results of surfactant substitution therapy in this model are presented.