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Suspected anaphylactoid shock to aminocaproic acid (plaslloid) during operation
1Department of Anesthesiology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|November 1, 1992
Summary
Epsilon-aminocaproic acid (plaslloid), a common hemostatic, rarely causes anaphylactoid shock. This case report details a severe reaction during cervical carcinoma surgery, emphasizing prompt management.
Area of Science:
- Anesthesiology
- Pharmacology
- Oncology
Background:
- Epsilon-aminocaproic acid (plaslloid) is a widely used perioperative hemostatic agent.
- While generally safe, rare adverse effects like anaphylactoid reactions can occur.
- Anaphylactoid shock is exceptionally uncommon, particularly under general anesthesia.
Observation:
- A patient undergoing elective cervical carcinoma surgery experienced a severe anaphylactoid reaction.
- The reaction presented with profound hypotension, tachycardia, hypoxemia, and edema.
- Symptoms suggested a link to plaslloid administration during the procedure.
Findings:
- The patient exhibited classic signs of anaphylaxis, including hemodynamic instability and cutaneous/mucosal edema.
- Prompt resuscitation with volume expansion and epinephrine was successful.
- This highlights the potential for severe allergic responses to plaslloid.
Implications:
- Anaphylactoid reactions to plaslloid, though rare, necessitate vigilance in perioperative settings.
- Early recognition and aggressive management are crucial for patient survival.
- Further investigation into the mechanisms of plaslloid-induced anaphylaxis may be warranted.