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Updated: Aug 1, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[int-2 and c-erbB-2 gene amplification in urological cancers]
1Department of Urology, Akita University School of Medicine, Japan.
Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|December 1, 1992
Summary
Gene amplifications of int-2 and c-erbB-2 are linked to transitional cell carcinoma progression. These genetic alterations were not found in renal or prostatic carcinomas, suggesting a specific role in urinary tract cancer development.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Transitional cell carcinoma (TCC) is a significant malignancy of the urinary tract.
- Understanding the genetic alterations driving TCC development and progression is crucial for targeted therapies.
Purpose of the Study:
- To investigate the amplification and rearrangement of int-2, c-erbB-2, and EGFR genes in various urinary tract carcinomas.
- To determine if these genetic alterations correlate with tumor grade, invasion, and recurrence in TCC.
Main Methods:
- Southern blot hybridization was employed to analyze gene alterations.
- The study included 32 cases of transitional cell carcinoma, 15 of renal cell carcinoma, and 14 of prostatic carcinoma.
Main Results:
- Int-2 gene amplification (3- to 12-fold) was detected in 12.5% of TCC cases, particularly in high-grade tumors with muscle invasion or recurrence.
- C-erbB-2 gene amplification was observed in 6.3% of invasive TCC cases.
- No significant amplification or rearrangement of EGFR, int-2, or c-erbB-2 genes was found in renal cell or prostatic carcinomas.
Conclusions:
- The int-2 gene (chromosome 11q13) and c-erbB-2 gene amplifications play a specific role in the carcinogenesis and progression of transitional cell carcinoma.
- These genetic alterations may serve as potential biomarkers for TCC aggressiveness and recurrence.
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