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Updated: Aug 11, 2026

Isolation, Culture, and Functional Characterization of Adult Mouse Cardiomyoctyes
Published on: September 24, 2013
[Molecular bases of cardiac aging]
L Carrier1, C Chassagne, K R Boheler
1INSERM U127, Hôpital Lariboisière, Paris.
Abstract:
The total volume occupied by myocytes in the heart decreases with age, and this is accompanied by a loss of myocytes, by hypertrophy and, to a lesser extent, by hyperplasia of the remaining myocytes. There are differences between ventricles: the right ventricular myocytes have a greater capacity for replication than those of the left ventricle. The expression of genes coding for the 2 principal contractile proteins (myosin and actin) is modified, and there are strong resemblances between the phenotype of the aged heart and that of an adult heart with haemodynamic overload.
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