Pathogenesis of carcinoma in operated stomach--an animal model

An experimental study on rats was performed to observe pathogenetic factors causing cancerogenesis in operated stomach. In sets I and II without exogenous carcinogen exposition 450 rats were operated upon by a different methods. In groups I it was B II gastrectomy, B II with Braun's anastomosis, B II in Roux en Y modification, B I and B I with jejunal interposition. In group II non-resective methods were tested: gastroenterostomy, gastroenterostomy with Braun's anastomosis, gastroenterostomy in Roux en Y modification, and vagotomy with pyloroplasty. In the group III 147 rats with different gastric operations were submitted to oral nitrate and nitrate with ascorbic acid exposition. The results confirmed significant pathogenetic influence of enterogastric reflux on cancerogenesis in the operated stomach. Ascorbic acid added to the exogenous cancerogen leads to a suppression of development of gastric cancer in rats.