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Updated: Jul 4, 2026
Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
Published on: June 29, 2015
[Guinea pig model of basilar artery thrombosis induced by ferric chloride]
Zhiqiang Luo1, Weijia Kong, Xianfeng Zhang
1Department of Otolaryngology, Second Affiliated Hospital of Nanhua University, Hengyang 421001.
Objective:
The present work was undertaken to establish an animal model of basilar arterial thrombosis.
Method:
The bilateral carotid arterial of guinea pigs were ligated and 40% ferric chloride solution was applied to basilar artery topically. The blood flow of cochlea(CBF) was measured continuously with laser doppler flow-meter. The mean arterial pressure (MABP) was recorded simultaneously. The data was analysed by t-test.
Result:
After the administration of 40% FeCl3 to basilar artery, The CBF began decrease significantly from 5 to 10 min, and declined more great along with the prolongation of FeCl3 effect. The CBF reached to (64.5 +/- 4.2)% of the base level at 50 min after FeCl3 exposure. A total average decrease of CBF was (81.3 +/- 12.0)% of the base level throughout the experiment period. The MABP had no significant change.
Conclusion:
The topical application of 40% FeCl3 solution can offer an ideal model of basilar artery thrombosis.
