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Rate of optic disc cup progression in treated primary open-angle glaucoma
Young H Kwon1, Young I Kim, Mary Lucy M Pereira
1Department of Ophthalmology and Visual Sciences, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA. young-kwon@uiowa.edu
Journal of Glaucoma
|October 2, 2003
Summary
In treated primary open-angle glaucoma patients, optic disc cupping progressed slowly at 0.0068 per year. Higher average intraocular pressure was linked to faster cup progression, highlighting its importance in managing glaucoma.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Optic Nerve Imaging
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Monitoring optic disc changes, specifically the cup-to-disc ratio (CDR), is crucial for assessing POAG progression.
- Longitudinal studies are essential to understand the rate of CDR progression in treated patients.
Purpose of the Study:
- To quantitatively assess the annual rate of CDR progression in treated POAG patients.
- To identify clinical factors, such as intraocular pressure (IOP), associated with the rate of optic disc cupping.
Main Methods:
- Analysis of longitudinal stereoscopic optic disc photographs from 51 treated POAG patients over a mean of 14.3 years.
- Computer-aided planimetry for measuring linear CDR and peripapillary atrophy.
- Linear regression to estimate CDR change over time and multiple regression to identify associated clinical factors.
Main Results:
- The mean rate of linear CDR progression was 0.0068 per year.
- Higher average yearly intraocular pressure was significantly associated with a faster rate of CDR progression (P = 0.03).
- Inter-observer and intra-observer reliability for CDR measurements were high (0.76 and 0.97, respectively).
Conclusions:
- Treated POAG patients exhibit a slow rate of progressive optic disc cupping.
- Elevated average intraocular pressure is a significant risk factor for accelerated CDR progression in POAG.