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Preferential attachment in the protein network evolution.

Eli Eisenberg1, Erez Y Levanon

  • 1Compugen Ltd., 72 Pinchas Rosen Street, Tel Aviv 69512, Israel.

Physical Review Letters
|October 4, 2003
PubMed
Summary
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Protein interaction networks evolve via preferential attachment, where older proteins become more connected over time. This suggests a growth mechanism similar to other complex networks.

Area of Science:

  • Systems Biology
  • Network Science
  • Evolutionary Biology

Background:

  • Many biological and man-made networks exhibit a scale-free topology.
  • The preferential attachment model is a proposed mechanism for generating scale-free networks.
  • It remains unclear if this model accurately describes protein-protein interaction network evolution.

Purpose of the Study:

  • To investigate the evolutionary mechanisms governing the Saccharomyces cerevisiae protein-protein interaction network.
  • To determine if preferential attachment plays a role in the development of this biological network.

Main Methods:

  • Cross-genome comparison of protein interaction data.
  • Analysis of protein age and connectivity.
  • Correlation analysis between interaction gain and existing connectivity.

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Main Results:

  • A positive correlation was found between protein age and its connectivity.
  • The number of new interactions acquired by a protein is proportional to its current connectivity.
  • These findings support the preferential attachment model for protein network evolution.

Conclusions:

  • Preferential attachment is a key evolutionary mechanism shaping protein-protein interaction networks.
  • Older, more established proteins tend to gain more interactions over evolutionary time.
  • Understanding these evolutionary dynamics offers insights into network robustness and function.