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Updated: Aug 30, 2026

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
Published on: May 24, 2017
Recognition of cyclonucleoside lesions by the Lactococcus lactis FPG protein
Evelyne Muller1, Didier Gasparutto, Bertrand Castaing
1Laboratoire des Lésions des Acides Nucléiques, Service de Chimie Inorganique et Biologique and UMR 5046, DRFMC-CEA/Grenoble, Grenoble, France.
Abstract:
Several purine and pyrimidine cyclonucleosides were found to be not recognized by several Escherichia coli and yeast DNA N-glycosylases. Interestingly, a non covalent complex was observed between the Lactoccocus lactis formamidopyrimidine-DNA glycosylases (Fpg-Ll) and the cyclonucleosides. This may provide new information on the mechanism involved in the activity of the latter enzyme.
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