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Updated: Aug 30, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Microwave-assisted ring-closing metathesis revisited. On the question of the nonthermal microwave effect
Stefania Garbacia1, Bimbisar Desai, Olivier Lavastre
1Institut de Chimie, UMR 6509 Universite de Rennes 1-CNRS, Campus de Beaulieu, 35042 Rennes, France.
Abstract:
The ring-closing metathesis reactions (RCM) of six standard diene substrates leading to five-, six-, or seven-membered carbo- or heterocycles were investigated under controlled microwave irradiation. RCM protocols were performed with standard Grubbs type II and a cationic ruthenium allenylidene catalyst in neat and ionic liquid-doped methylene chloride under sealed vessel conditions. Very rapid conversions (15 s) were achieved utilizing 0.5 mol % Grubbs II catalyst under microwave conditions. Careful comparison studies indicate that the observed rate enhancements are not the result of a nonthermal microwave effect.
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