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Glucose-regulated stress proteins and antibacterial immunity
Ulrike K Rapp1, Stefan H E Kaufmann
1Max Planck Institute for Infection Biology, Schumannstrasse 21-22, 10117 Berlin, Germany. rapp@mpiib-berlin.mpg.de
Trends in Microbiology
|November 11, 2003
Abstract:
The role of stress proteins in immunity and their feasibility as vaccine vehicles against infectious disease have been the focus of intensive examination. Endoplasmic reticulum (ER)-resident stress proteins in particular are interesting model proteins as they perform crucial functions in an organelle that responds promptly to cell stress. We describe transcriptional regulation of ER-resident stress proteins, their involvement in the cellular response to infection and discuss their potential as vaccine candidates against infectious diseases.