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Hypersensitivity to progesterone-in-oil after in vitro fertilization and embryo transfer
Jennifer L Phy1, William T Weiss, Catherine R Weiler
1Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA. phy.jenniferlynn@mayo.edu
Objective:
To report the occurrence and management of pulmonary compromise, marked leukocytosis, and eosinophilia in a patient receiving P-in-oil after IVF and embryo transfer.
Design:
Case report.A tertiary referral reproductive medicine unit.
Patient(S):
A 29-year-old patient receiving P-in-oil supplementation after IVF embryo transfer.
Intervention(S):
Extensive diagnostic testing and surveillance for hypersensitivity to P in sesame oil; development of an alternative oil-based P-in-oil suspension.
Main Outcome Measure(S):
Tolerance of alternative P vehicle; clinical pregnancy.
Result(S):
The patient tolerated an alternative P oil vehicle and successfully achieved a clinical pregnancy after frozen embryo transfer.
Conclusion(S):
Although rare, hypersensitivity reactions may occur in patients receiving P-in-oil supplementation after IVF embryo transfer. Testing for tolerance and subsequent use of alternative P vehicles may be an effective strategy in managing patients with sensitivity to P-in-oil.
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