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Prenatal hypoxia and early postnatal maturation of the chemoafferent pathway

Julie Peyronnet1, Jean-Christophe Roux, David Perrin

  • 1Laboratoire de Physiologie des Régulations Métaboliques, Cellulaires et Moléculaires, UMR CNRS 5123, Faculté de Médecine, 8 avenue Rockefeller, 69 373 Lyon cedex 08, France.

Advances in Experimental Medicine and Biology
|November 26, 2003
PubMed
Abstract

No abstract available in PubMed .

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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