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Neuroblastoma: management, recurrence, and follow-up
Keith L Lee1, Jian F Ma, Linda D Shortliffe
1Department of Urology, S-287 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5118, USA.
The Urologic Clinics of North America
|December 19, 2003
Abstract:
The clinical use of N-myc amplification in neuroblastoma management has served as a paradigm for "bench to bedside" medicine. It is hoped that the quest for molecular markers such as neurotrophin, TrkA, and TrkB will continue to advance the understanding of neuroblastoma. In addition, animal models of neuroblastoma (N-myc transgenic mice, and neuroblastoma xenografts) have been established to assess the efficacy of novel treatments. These advances are likely to improve clinical practice in the future.