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Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase

Aimin Song1, Xiaobing Wang, Jinhua Zhang

  • 1Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California-Davis, 4501 X Street, Sacramento, CA 95817, USA.

Bioorganic & Medicinal Chemistry Letters
|December 20, 2003
PubMed

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Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...