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Preparation of a biodegradable matrix through polyion complex formation by mixing polylactide-based microspheres
Hidetoshi Arimura1, Yuichi Ohya, Tatsuro Ouchi
1Faculty of Engineering and High Technology Research Center, Kansai University, Suita, 564-8680 Osaka, Japan. gf2d401@ipcku.kansai-u.ac.jp
Abstract:
The aggregation of polyions into microsphere (MS) complexes was studied as a preparative method for the construction of a biodegradable matrix. Aqueous suspensions of polylactide (PLA)-based MSs with positively and negatively charged surfaces, MS(K(3)(4+)-PLA) and MS(E(3)(4-)-PLA), respectively, immediately formed aggregates when mixed. The effects of the stoichiometry of the charged groups on the surfaces of the MSs and the ionic strength of the medium on aggregate formation, as well as the degradation behavior of the polyion complex (PIC) matrix over time, were investigated.