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Changing patterns of intraocular inflammatory disease in Japan
Toshiko Wakabayashi1, Yoshihiro Morimura, Yuko Miyamoto
1Kyorin Eye Center, Kyorin University School of Medicine, Tokyo, Japan. aokada@po.iijnet.or.jp
Purpose:
We investigated the frequencies and clinical characteristics of Japanese patients with uveitis.
Methods:
Records of 189 patients referred from April 1999 to March 2001 were retrospectively reviewed.
Results:
Fifty-six patients (29.6%) had anterior uveitis, 13 (6.9%) intermediate uveitis, 59 (31.2%) posterior uveitis, 58 (30.7%) panuveitis, and three (1.6%) papillitis. The most common diagnoses were Vogt-Koyanagi-Harada (VKH) disease (10.1%), biopsy-proven or presumed sarcoidosis (9.5%), acute anterior uveitis (7.9%), tuberculosis (6.9%), and Behçet's disease (5.8%). Seventy-three patients (38.6%) were treated with local therapy alone, and 95 patients (50.3%) required systemic therapy. Ocular complications developed in 19.6% of patients, and systemic complications in 2.1%.
Conclusions:
These results confirm a continued high frequency of VKH disease and sarcoidosis, but suggest a decreased frequency of Behçet's disease and an increased frequency of tuberculosis. Roughly one-half of the patients required systemic treatment in addition to local therapy, and ocular and/or systemic complications developed in one-fifth of the patients.