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TurboFLASH FAIR imaging with optimized inversion and imaging profiles.

Gaby S Pell1, David P Lewis, Roger J Ordidge

  • 1Department of Medical Physics, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA. g.pell@brain.org.au

Magnetic Resonance in Medicine
|January 6, 2004
PubMed
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Optimizing pulsed arterial spin labeling (PASL) with a novel TurboFLASH sequence significantly reduces the slice thickness ratio (STR). This improves arterial spin labeling (ASL) methods by minimizing transit time effects.

Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Neuroimaging

Background:

  • Pulsed arterial spin labeling (PASL) methods like FAIR require minimizing inversion and imaging slab interactions.
  • The inversion:imaging slice thickness ratio (STR) is typically 3:1, leading to transit time issues.
  • Existing methods focus on inversion profiles, neglecting the imaging profile's impact on rapid sequences.

Purpose of the Study:

  • To implement a TurboFLASH sequence with optimized inversion and imaging profiles for PASL.
  • To reduce the slice thickness ratio (STR) and minimize transit time effects.
  • To enhance the performance and applicability of arterial spin labeling (ASL) techniques.

Main Methods:

  • Developed a TurboFLASH sequence with optimized inversion and imaging profiles.

Related Experiment Videos

  • Utilized adiabatic frequency offset corrected inversion (FOCI) pulses for slice selection.
  • Investigated RF and gradient schemes and relaxation characteristics.
  • Validated through phantom experiments and implementation in an animal model.

    • Main Results:

    • Achieved a significant reduction in the STR to approximately 1.13:1.
    • Demonstrated the sequence's effectiveness in an animal model.
    • Showcased the ability to probe flow signal sensitivity to tagging geometry.
    • Confirmed minimization of sensitivity to transit time effects.

    Conclusions:

    • The optimized TurboFLASH sequence with improved slice profiles enhances ASL methodologies.
    • Reduced STR and minimized transit time effects lead to more accurate and reliable ASL imaging.
    • This advancement facilitates broader exploration and application of ASL techniques.