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Updated: Aug 29, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Computed tomography for assessment of cardiac chambers, valves, myocardium and pericardium
Lawrence M Boxt1, Martin J Lipton, Raymond Y Kwong
1Division of Cardiovascular Imaging, Beth Israel Medical Center, 1st Avenue at 16th St., New York, NY 10003, USA.
Insights
Multi-detector row CT (MDCT) shows promise for cardiac diagnosis, but its role in heart disease is still evolving. Improvements in temporal resolution and hardware are key to realizing the full potential of CT imaging.
Area of Science:
- Cardiovascular imaging
- Medical imaging technology
- Diagnostic radiology
Background:
- Current CT applications focus on coronary arteries, including calcification, plaque, and stenosis.
- Limited temporal resolution of CT has historically favored MRI for cardiac applications.
- Electron beam tomography (EBT) has established CT feasibility for general cardiac diagnosis.
Purpose of the Study:
- To explore the evolving role of multi-detector row CT (MDCT) in cardiac diagnosis.
- To discuss the potential of improved MDCT temporal resolution for future validation studies.
- To compare MDCT with other cardiac imaging modalities.
Main Methods:
- Review of current MDCT applications and limitations in cardiac imaging.
- Discussion of technological advancements in MDCT, including software and hardware.
- Comparison of MDCT with electron beam tomography (EBT) and MRI.
Main Results:
- MDCT's primary focus remains on coronary artery evaluation due to temporal resolution limits.
- Advancements in MDCT software and hardware aim to improve temporal resolution and image acquisition speed.
- EBT technology is also advancing, with new scanners offering exposure times of 50 msec or less.
Conclusions:
- The ultimate role of CT in diagnosing heart disease is not yet fully established.
- Further CT validation studies are warranted if temporal resolution can be improved.
- Factors like accuracy, convenience, cost, and patient/physician acceptance are critical in choosing imaging modalities.
Abstract:
The focus to date of MDCT has been primarily on CT applications for evaluating the coronary arteries, notably the measurement of coronary artery calcification, plaque characterization, and atherosclerotic lumen stenosis. This is because of the limited temporal resolution of CT, and the recent rapid improvements in MRI for cardiac applications. However, if the temporal resolution of MDCT can be improved, there will be a compelling argument for undertaking further CT validation studies. Feasibility of CT has already been established by EBT for general cardiac diagnosis. Modifications for MDCT include improved software methods for post processing ECG-gated scan data or higher speed CT hardware for faster image acquisition, both of which are being developed at this time. EBT is also evolving and continuously being refined so that the new generation of scanners have exposure times of 50 msec or less. There are many considerations in comparing the pros and cons of competing cardiac imaging modalities. Published diagnostic validations studies, convenience, procedure time, the comfort level (of patients and physicians), availability, and cost are all critical. The level of acceptance and the accuracy with which specific patient management questions can be appropriately answered are crucial issues in determining which diagnostic procedure to perform. However, the jury is still out regarding the ultimate role of CT in the diagnosis of heart disease; certainly the great potential of cardiac CT has not yet been fully realized.
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