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Related Experiment Videos

Endoscopic vertical partial laryngectomy.

R Kim Davis1, Kevin Hadley, Marshall E Smith

  • 1Division of Otolaryngology-Head and Neck Surgery, 3C120 School of Medicine, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA.

The Laryngoscope
|February 3, 2004
PubMed
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Endoscopic vertical partial laryngectomy (EVPL) effectively treats T1b and T2a glottic cancers. EVPL combined with postoperative irradiation shows an 85% local control rate for T2 glottic cancers with impaired vocal cord mobility.

Area of Science:

  • Otolaryngology
  • Oncology
  • Surgical Oncology

Background:

  • Glottic squamous cell carcinoma presents treatment challenges, particularly for T1b and T2 stages.
  • Endoscopic vertical partial laryngectomy (EVPL) offers a less invasive alternative to traditional cordectomy.
  • Vocal cord mobility status and anterior commissure involvement are critical prognostic factors.

Purpose of the Study:

  • To differentiate EVPL from microlaryngoscopy with cordectomy.
  • To assess EVPL efficacy for T1b and T2 glottic squamous cell carcinoma.
  • To evaluate EVPL with postoperative irradiation for T2 glottic cancer with impaired vocal cord mobility.

Main Methods:

  • Retrospective review of 26 patients with T1b or T2 glottic squamous cell carcinoma treated with EVPL.

Related Experiment Videos

  • Patients were stratified based on tumor stage, mobility, and anterior commissure involvement.
  • Treatment arms included surgery alone (T1b, T2a) or surgery followed by irradiation (T2 with impaired mobility).

    • Main Results:

    • EVPL alone achieved 100% local control for T1b and T2a glottic cancers, including those with >50% anterior commissure involvement.
    • For T2 glottic cancers with impaired vocal cord mobility (T2ai, T2bi), EVPL with postoperative irradiation yielded an 84.5% local control rate.
    • Overall survival was 88.5%, with two recurrences salvaged by total laryngectomy.

    Conclusions:

    • EVPL is a highly effective organ-preserving surgical option for T1b and T2a glottic squamous cell carcinoma.
    • Combined EVPL and postoperative irradiation provides good local control for select T2 glottic cancers with compromised vocal cord mobility.
    • EVPL offers a distinct advantage over traditional cordectomy, preserving laryngeal function while achieving oncologic control.