Animal prostate carcinoma models: limited potential for vertebral metastasis

Several methods for induction of rat prostate carcinomas are now available. The induced adenocarcinomas, which develop normally in the lateral and/or dorsal prostate, are invasive and can form distant metastases. Metastatic sites include the abdominal cavity, liver, lung, and/or lymph nodes but, as yet, bone metastasis of prostate cancers in experimental animals has not been reported, despite its being very common in man. Anatomical and hemodynamic differences seem to be account for this lack of bone metastasis.