Spatiotemporal characteristics of glycogen content in rat liver lobule

We evaluated spatiotemporal characteristics of glycogen content in cells of rat liver lobule. Glycogen content in the liver lobule and its circulatory subzones underwent diurnal fluctuations with acrophase at 5.00. Spatial changes were characterized by a dependence of gradients in the lobule on the phase of diurnal rhythmic fluctuations. Total glycogen content in the peripheral subzone of the lobule 5.2-fold surpassed that in the central subzone. Our results illustrate spatiotemporal organization of glycogen content in the liver lobule.