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A direct meta-lithiation route to 1,3-disubstituted ferrocenes
Christophe Pichon1, Barbara Odell, John M Brown
1Dyson Perrins Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, UK OX1 3QY.
Chemical Communications (Cambridge, England)
|February 20, 2004
Abstract:
Ferrocenyl sulfides afford meta-lithiation products with up to 94% regioselectivity on reaction with s-BuLi; the resulting 1,3-disubstituted ferrocenes can then be reacted with a variety of electrophiles.