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Related Experiment Videos

[Phenotypic changes in human bladder smooth muscle cell].

Seiji Matsumoto1, Tadashi Hanai, Takashi Kurita

  • 1Department of Urology, Kinki University School of Medicine.

Hinyokika Kiyo. Acta Urologica Japonica
|February 26, 2004
PubMed
Summary
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[LYMPH NODE TUBERCULOSIS AFTER INTRAVESICAL BACILLUS CALMETTE-GUÉRIN THERAPY FOR BLADDER CARCINOMA IN SITU : A CASE REPORT].

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Bladder diseases alter smooth muscle cell phenotypes, increasing the non-contractile to contractile ratio. This change, particularly in neurogenic bladder, may impact detrusor function.

Area of Science:

  • Urology
  • Cell Biology
  • Smooth Muscle Physiology

Context:

  • Bladder smooth muscle cells exhibit phenotypic plasticity, similar to vascular smooth muscle cells.
  • Aging and various bladder diseases influence the contractile and non-contractile phenotypes of bladder smooth muscle cells.

Purpose:

  • To investigate the phenotypic expression of bladder smooth muscle cells in patients with diverse bladder diseases.
  • To determine the relationship between aging, bladder disease, and the non-contractile to contractile (nc/c) ratio in bladder smooth muscle cells.

Summary:

  • Tissue specimens from 15 patients (ages 7-82) with conditions including neurogenic bladder, post-kidney transplant defunctionalized bladder, benign prostatic hypertrophy, bladder cancer, and vesicoureteral reflux were analyzed.
  • A rising non-contractile to contractile (nc/c) ratio was observed with aging, with a particularly notable increase in neurogenic bladder cases.

Related Experiment Videos

  • Bladder diseases induce a phenotypic conversion of smooth muscle cells from contractile to non-contractile types, suggesting a role in detrusor dysfunction.

    • Impact:

    • Findings reveal that bladder diseases induce significant alterations in smooth muscle cell phenotype.
    • The modulation of smooth muscle cell phenotype is implicated as a key factor in detrusor muscle function.
    • This research provides insights into the cellular mechanisms underlying bladder disease pathophysiology.