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Burkitt's lymphoma presenting as obstructive jaundice

R D Wammanda1, F U Ali, S J Adama

  • 1Department of Paediatrics, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. wammanda@inet-global.com

Annals of Tropical Paediatrics
|March 10, 2004
PubMed

Insights

Pediatric Burkitt's lymphoma can rarely present as obstructive liver disease. Early diagnosis and chemotherapy led to jaundice resolution in a 12-year-old boy.

Area of Science:

  • Pediatric Oncology
  • Hepatology
  • Hematology

Background:

  • Burkitt's lymphoma is an aggressive non-Hodgkin lymphoma common in children.
  • Hepatic involvement in Burkitt's lymphoma is uncommon, and presentation as primary obstructive jaundice is rare.

Observation:

  • A 12-year-old boy presented with a 5-month history of jaundice, abdominal swelling, and weight loss.
  • Physical examination revealed marked jaundice and hepatomegaly in a wasted child.
  • Liver function tests and ultrasound indicated obstructive liver disease.

Findings:

  • Laparotomy with tissue biopsy confirmed Burkitt's lymphoma.
  • The patient received two courses of cytotoxic chemotherapy.
  • Post-chemotherapy, jaundice resolved, and the patient's condition improved.

Implications:

  • This case highlights the importance of considering Burkitt's lymphoma in the differential diagnosis of pediatric obstructive jaundice.
  • Prompt diagnosis and treatment of hepatic Burkitt's lymphoma can lead to favorable outcomes.
  • Rare presentations of common childhood cancers necessitate broad diagnostic considerations.

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