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Updated: Aug 25, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activion

G Richter1, S Burdach

  • 1Labor für Transplantationsbiologie, Kinderklinik und Poliklinik des Klinikums rechts der Isar der Technischen Universität München, Germany. guenther.richter@lrz.tum.de

Onkologie
|March 10, 2004
PubMed

The inducible costimulator (ICOS) is a new member of the CD28/CD152 receptor family that regulates T-cell activation and function. ICOS binds to a specific ligand on antigen-presenting cells (APC) and cells of the peripheral tissue different from the CD28/CD152 ligands CD80 and CD86. ICOS-L can be induced by inflammatory stimuli in peripheral tissue and on some APC, including monocytes, but is downregulated in B-cell and myeloid leukemia. ICOS-L delivers distinct signals to T cells, presumably important for the maintenance of certain types of immune response, providing the rationale for the development of new therapeutic strategies for the treatment of diseases.

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