Clinical applications of event-related potentials in brain injury

ERPs may extend the battery of neurophysiologic tests currently available for determining the functional integrity of the central nervous system and the capacity of cognition in patients with brain injury. The use of stimuli relevant for the patient can enhance the probability to record these waves in unconscious patients and in patients with cognitive impairment and enhance the predictive value on outcome. The experimental data in these patients still are not sufficient, however, to standardize the indications of ERPs in clinical practice. Their limitations, mainly the variability also present in normal individuals and the limited standardization and validation, must be considered, and they must be judged cautiously as a prognostic index. Nevertheless, ERPs might be applied as a useful supplement to neuropsychologic assessment.