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Related Experiment Videos

Unlocking the code of 14-3-3.

Michele K Dougherty1, Deborah K Morrison

  • 1Laboratory of Protein Dynamics and Signaling, NCI-Frederick, Frederick, MD 21702, USA.

Journal of Cell Science
|April 20, 2004
PubMed
Summary
This summary is machine-generated.

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The 14-3-3 protein, initially found in the brain, is crucial for cell signaling. It binds to over 100 partners, regulating diverse cellular functions and impacting diseases.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • 14-3-3 proteins were first identified as abundant brain proteins.
  • Their role expanded significantly upon discovery of interactions with proto-oncogenes and signaling proteins.
  • 14-3-3 proteins are conserved across eukaryotes and bind phosphoserine/phosphothreonine motifs.

Purpose of the Study:

  • To summarize the diverse roles and regulatory functions of 14-3-3 proteins in cell biology.
  • To highlight the importance of 14-3-3 proteins in cell signaling pathways.
  • To explore the involvement of 14-3-3 proteins in various diseases.

Main Methods:

  • Literature review of studies on 14-3-3 protein interactions and functions.
  • Analysis of identified 14-3-3 binding partners and their subcellular localization.

Related Experiment Videos

  • Examination of recent findings on 14-3-3 regulation by protein phosphatases and its role in disease.

    • Main Results:

    • Over 100 binding partners identified, affecting diverse cellular processes.
    • 14-3-3 binding modulates target protein localization, stability, activity, and interactions.
    • Protein phosphatases PP1 and PP2A regulate 14-3-3 interactions.
    • 14-3-3 proteins control protein translocation to the plasma membrane.
    • 14-3-3 proteins are implicated in neoplastic and neurological disorders.

    Conclusions:

    • 14-3-3 proteins are essential regulators of cell signaling and function.
    • Their dysregulation is linked to disease pathogenesis.
    • Further research into 14-3-3 functions may reveal therapeutic targets.