Related Experiment Videos
Acute necrotizing esophagitis: a large retrospective case series
F Augusto1, V Fernandes, M I Cremers
1Department of Gastroenterology, S Bernardo Hospital, Setúbal, Portugal.
Endoscopy
|April 22, 2004
Summary
Acute necrotizing esophagitis, a rare condition, occurred in 0.28% of upper endoscopies. This serious esophageal issue primarily affects elderly males with comorbidities and presents as upper gastrointestinal bleeding.
Area of Science:
- Gastroenterology
- Esophageal Diseases
Background:
- Acute necrotizing esophagitis (ANE) is a rare esophageal condition with an unknown etiology and incidence.
- Previous reports on ANE are limited, necessitating further investigation into its clinical characteristics.
Purpose of the Study:
- To determine the incidence of ANE.
- To describe the clinical presentation, endoscopic findings, and outcomes of ANE.
- To explore accompanying factors and potential pathogenesis of ANE.
Main Methods:
- A 5-year retrospective analysis of clinical, laboratory, endoscopic, and histological data from 29 ANE patients.
- Review of upper gastrointestinal endoscopy records to establish incidence.
Main Results:
- ANE was identified in 0.28% of 10,295 upper endoscopies.
- Patients were predominantly elderly males (average age 75.24 years) with significant comorbidities (83%).
- All cases presented with upper gastrointestinal bleeding; lesions affected the lower esophagus, and prognosis was linked to age and comorbidities.
Conclusions:
- ANE is more prevalent than previously thought and a critical consideration in upper gastrointestinal bleeding, especially in the elderly.
- The condition resolved in all patients, but mortality was associated with advanced age and comorbid illnesses.
- ANE prognosis is primarily influenced by patient factors rather than the esophageal lesions themselves.