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Related Experiment Videos

Human cardiac nerve stimulation.

D A Murphy1, J A Armour

  • 1Department of Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

The Annals of Thoracic Surgery
|September 1, 1992
PubMed
Summary
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Electrical stimulation of cardiac nerves in patients altered heart function. Different neural targets produced distinct cardiovascular responses, similar to findings in mammals.

Area of Science:

  • Cardiology
  • Neuroscience
  • Cardiac Electrophysiology

Background:

  • The extrinsic and intrinsic cardiac nervous systems modulate cardiovascular function.
  • Understanding these neural pathways in humans is crucial for cardiac surgery and treatment.

Purpose of the Study:

  • To investigate the effects of stimulating specific human cardiac neural elements on cardiodynamics.
  • To compare responses from extrinsic (aortic-pulmonary) and intrinsic (right atrial ganglionated plexus) cardiac nervous systems.

Main Methods:

  • Electrical stimulation of cardiopulmonary neural elements in 12 patients undergoing cardiac operations.
  • Monitoring of heart rate, left ventricular, and right ventricular intramyocardial systolic pressures.

Main Results:

Related Experiment Videos

  • Stimulation of cardiopulmonary nerves between the aorta and pulmonary artery augmented heart rate and left ventricular pressure in 11/12 patients.
  • Right ventricular pressure increased in 7/11 patients following aortic-pulmonary nerve stimulation.
  • Stimulation of the right atrial ganglionated plexus elicited cardiodepressor responses in 9/12 patients.

Conclusions:

  • Electrical stimulation of human extrinsic and intrinsic cardiac nervous systems can significantly alter cardiodynamics.
  • Distinct neural structures within the cardiac nervous system elicit different cardiovascular responses.
  • Findings suggest functional similarities between human and canine cardiac neural elements.