Related Experiment Videos
Strategies leading to MT2 selective melatonin receptor antagonists
Gilberto Spadoni1, Annalida Bedini, Giovanni Piersanti
1Istituto di Chimica Farmaceutica e Tossicologica, Università degli Studi di Urbino, Piazza Rinascimento 6, I-61029 Urbino, Italy. gilberto@uniurb.it
Advances in Experimental Medicine and Biology
|June 23, 2004
Abstract:
Studies of the physiological actions of melatonin have been hindered by the lack of specific, potent and subtype selective agonists and antagonists. This paper reviews our progress in developing subtype selective melatonin antagonists. Evidence is presented suggesting the structural features conferring MT2 selective antagonism.