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Linkage analysis and predicting genetic disease
J A Boughman1, M J Stick, D A Peterson
1Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore.
Clinics in Laboratory Medicine
|September 1, 1992
Abstract:
Linkage analysis is an important and clinically applicable method of predicting risk for genetic disorders and traits. When a gene cannot be detected directly, evaluation of a closely linked marker may be used in risk assessment. This review of linkage analysis provides basic information and examples of the application of these methods in genetic counseling situations.