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Optical energy transfer for intraocular microsystems studied in rabbits
Thomas Laube1, Claudia Brockmann, Rüdiger Buss
1Department of Ophthalmology, Duisburg-Essen University, Hufelandstrasse 55, 45147 Essen, Germany. thomas.laube@uni-essen.de
Summary
Photovoltaic power generation in intraocular lenses (IOLs) is feasible for visual prostheses. This study demonstrated long-term in vivo function of photovoltaic cells in rabbit implants, paving the way for future retinal prostheses.
Area of Science:
- Biomedical Engineering
- Ophthalmology
- Materials Science
Background:
- Visual prostheses aim to restore vision in patients with photoreceptor loss.
- Retinal implant power can be supplied via electromagnetic induction or optical energy transfer.
- This study explores photovoltaic power generation within an intraocular lens (IOL) for epiretinal implants.
Purpose of the Study:
- To investigate the feasibility of photovoltaic power generation in an IOL for long-term epiretinal implant testing.
- To assess the in vivo functionality and longevity of photovoltaic cells integrated into an IOL.
- To evaluate the biocompatibility of such implants in a rabbit model.
Main Methods:
- Intraocular lenses (IOLs) with photovoltaic cells (PVC) and LEDs were implanted in chinchilla rabbits.
- Optical energy transfer was achieved using an 850 nm infrared laser.
- Implant function was monitored, and explanted devices underwent technical and histological analysis.
Main Results:
- Microsystem lifespans varied from 14 days to over 7 months.
- Malfunctions were attributed to PVC defects or poor adhesion of the silicone cover.
- Histological examination revealed no retinal structure alterations in treated eyes.
Conclusions:
- Photovoltaic power supply for intraocular microsystems is feasible based on long-term rabbit studies.
- Hermetic coating of electronic components is crucial for future device reliability.
- This approach shows promise for powering visual prostheses.