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Updated: Aug 23, 2026
An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
[Expression of focal adhesion kinase in laryngeal carcinoma]
Feng Yu1, Yuli Dong, Yuelong Jiao
1Department of Otolaryngology-Head and Neck Surgery, Guangzhou Hospital of Otolaryngology-Head and Neck Surgery, Guangzhou, 510620, China.
Objective:
To evaluate the pattern of FAK expression in laryngeal squamosa cell carcinoma and non-carcinoma tissue.
Method:
Expression of FAK was examined in 100 specimens with laryngeal squamosa cell carcinoma and 60 specimens with non-carcinoma, in which 8 cases were in stage I, 23 cases in stage II, 38 cases in stage III and 31 cases in stage IV.
Result:
The staining of FAK was stronger in laryngeal squamous cell carcinomas than in the cell of non-carcinoma areas. The cancers with lymphnode metastasis had more FAK protein than the cancers with out lymph node metastasis. Survival rate at 3 and 5 years was 76.9%(50/65) and 61.5%(40/65) respectively for positive staining group of FAK, compared to 97.1%(34/35) and 88.6% (31/35) respectively for negative staining group.
Conclusion:
The results in the report show that the level of FAK expression might be a valuable marker for carcinogeneandsis and the progression of carcinoma.
