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Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
Published on: May 21, 2017
Predictable changes in left ventricular mass and function during ten years after valve replacement for aortic
Ole Lund1, Mogens Erlandsen, Inge Dørup
1Department of Cardiothoracic Surgery, Aarhus University Hospital, Skejby, Denmark. olelund@ntlworld.com
The Journal of Heart Valve Disease
|June 30, 2004
Summary
Long-term left ventricular mass reduction after aortic valve replacement for aortic stenosis is predictable. Preoperative hypertrophy, hypertension, and male gender influence outcomes, while prosthetic valve function does not impact results.
Area of Science:
- Cardiology
- Cardiac Surgery
- Cardiovascular Imaging
Background:
- Left ventricular (LV) hypertrophy is crucial for longevity post-aortic valve replacement (AVR) for aortic stenosis (AS).
- Long-term changes in LV mass and function after AVR are not fully understood.
- Determinants of these long-term changes require detailed investigation.
Purpose of the Study:
- To analyze long-term changes in LV mass and function up to 10 years after AVR for AS.
- To identify predictors of these changes in LV mass and function.
- To assess the impact of patient-specific factors and prosthetic valve characteristics on outcomes.
Main Methods:
- Ninety-one adult patients with AS underwent AVR and were followed for up to 10 years.
- LV mass index (LVMi), ejection fraction (LVEF), fast filling fraction (LVFFF), and end-diastolic volume index (LVEDVi) were measured.
- Longitudinal regression models analyzed repeated measures in a subgroup of 49 patients.
Main Results:
- LVMi progressively reduced to 1.5 years post-AVR, with no significant change thereafter.
- Improvements in LVEF and LVEDVi were observed, paralleling LVMi reduction.
- Predictors of poorer outcomes included preoperative LV hypertrophy, hypertension, and male gender; prosthetic valve function had no impact.
Conclusions:
- LV mass and function changes after AVR for AS are highly predictable.
- Preoperative LV hypertrophy and comorbidities like hypertension and coronary artery disease negatively influence outcomes.
- Prosthetic aortic valve hemodynamics do not play a significant role in long-term LV remodeling.
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