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Updated: Aug 23, 2026

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation
Published on: November 6, 2014
Ubiquitin-mediated proteolysis: an ideal pathway for systems biology analysis
1Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Abstract:
Ubiquitin is a small, evolutionarily conserved eukaryotic protein that can be attached to a wide variety of intracellular proteins including itself. Covalent attachment of ubiquitin to other proteins serves various functions, but its major role is to target cellular proteins for destruction. Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach.
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